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NCI Campus, Rockville, Maryland |
From 2005-2012, the National Cancer Institute (NCI) in the US averaged an amount of $4.9 billion each year being put into cancer-related research.
Cancer Research UK spent £332 million on research activity in the 2011-2012 financial year.
Cancer research and treatment development consumes massive amounts of funding every year, but the cure for this universally-feared disease remains just out of reach.
Cancer cells, to a biologist, are pockets of chemical reactions and processes, capable of causing significant damage to healthy, living cells and genetic mutations in their cell recruits. Despite substantial funding which has fed into this all-important research, the US, for example, has seen a 5% decrease in cancer-related deaths since 1950. Although this is still an incredible number of lives saved, what more can be done to save future lives?
Perhaps the key to unlocking the mysterious fix lies with not a cancer biologist, but with a new type of mind - a physicist's mind.
In 2008, the NCI built 12 centres for physical science and oncology, designed for physicists, engineers and mathematicians to shed new light on cancerous cell behaviour.
Cells may be living things, but a physicist will consider other things than it's matter and behaviour: how about a cell's shape? Features in its structure such as pumps and levers? Properties of the membrane, the texture and design of the cell surface? "Many of these properties are known to change systematically as cancer progresses in malignancy."
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Metastasis of the cancerous cells from the primary tumour. |
Metastasis is the spread of cancer from its original position to another organ of the body. It is this which makes cancer so deadly.
Even if the primary tumour is removed, there is always the possibility that a new tumour could form and cause problems years later, due to a cancerous cell's ability to spread by entering the blood's circulation.
Four years after NCI proposed that physicists take a look at cancer, discoveries have been made concerning how the shape of a cancer cell changes during metastasis. Some are able to release "little molecular grappling hooks" or 'cadherins' to grip onto a blood vessel wall and 'nest' in the nearest organ.
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Areolar extracellular matrix. |
The new organ tissue may seem foreign but new research shows that cancer cells are able to alter the structure of the foreign organ's extracellular matrix - this section of tissue provides structural and defensive support to important tissues and organs.
So perhaps with the combined powers of biological and physical scientists, research for the treatment and ultimately cure for cancer will make some interesting leaps and bounds in the right direction. I think we should bring the three streams of science together more often (let's not forget Chemistry!), allowing different perspectives to be directed at the same problem. Surely things would be solved faster that way? No?
References: New Scientist, Wikipedia, National Cancer Institute, Cancer Research UK